Two Cases of Multidrug-Resistant Human Immunodeficiency Virus Infection Treated with Atazanavir and Lopinavir/Ritonavir Combination Therapy
Journal of Korean Medical Science
; : 737-739, 2008.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-123473
Biblioteca responsable:
WPRO
ABSTRACT
The combination of atazanavir (ATV) and lopinavir/ritonavir (LPV/RTV) with nucleoside reverse transcriptase inhibitors (NRTI) has been used as a salvage regimen for human immunodeficiency virus (HIV)-positive patients. In this paper, we discuss two cases of HIV-positive patients who had long histories of virological failure following a heavy treatment of antiretroviral drugs, but then achieved virological suppression with double-boosted protease inhibitor (PI) regimens. In patients with multiple genotypic resistance to PIs and NRTIs, virological suppression can be achieved with a combination of ATV plus LPV/RTV with an NRTI backbone. The two cases in this report suggest that a combination of ATV plus LPV/RTV could be a useful salvage regimen for the subset of HIV-positive patients with limited treatment options.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Oligopéptidos
/
Piridinas
/
Pirimidinonas
/
Infecciones por VIH
/
Inhibidores de la Proteasa del VIH
/
Ritonavir
/
Farmacorresistencia Viral Múltiple
/
Quimioterapia Combinada
Límite:
Adulto
/
Humanos
/
Masculino
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2008
Tipo del documento:
Artículo