Leptin is Associated with Endothelial Dysfunction in Healthy Obese Premenopausal Women
Korean Circulation Journal
; : 251-257, 2007.
Article
en En
| WPRIM
| ID: wpr-124128
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: Previous studies have demonstrated that adipokines can have positive and/or negative effects on vascular function. In this study, we attempted to characterize the association of adipokines with endothelium-dependent vasodilation in healthy premenopausal women. SUBJECTS AND METHODS: Noninvasive pulse wave analysis coupled with provocative pharmacological testing with salbutamol was used to measure endothelium-dependent vasodilation in 60 healthy premenopausal women [37 obese women; body mass index (BMI) > or = 25 kg/m2, 23 age-matched non-obese women; BMI<25 kg/m2]. The lipid profile, fasting insulin, glucose, and C-reactive protein (CRP) concentrations in each patient were assessed via standard laboratory techniques, and plasma concentrations of various adipokines, such as adiponectin, leptin, resistin and TNF-alpha, were measured via enzyme immunoassays. RESULTS: In the obese group, higher leptin concentrations were significantly associated with impairments in endothelium-dependent vasodilation (r=-0.371, p=0.005). This association remained significant, even after adjustment for other risk factors (beta=-0.39, p=0.006). However, we determined that there was no significant correlation between endothelium-dependent vasodilation and these variables in the obese group and the control group. CONSLUSION: Increased plasma concentration of leptin was associated with impairment in endothelial function in obese premenopausal women, regardless of the metabolic and inflammatory disturbances associated with obesity.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Plasma
/
Vasodilatación
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Proteína C-Reactiva
/
Índice de Masa Corporal
/
Factores de Riesgo
/
Técnicas para Inmunoenzimas
/
Ayuno
/
Factor de Necrosis Tumoral alfa
/
Leptina
/
Albuterol
Tipo de estudio:
Etiology_studies
/
Risk_factors_studies
Límite:
Female
/
Humans
Idioma:
En
Revista:
Korean Circulation Journal
Año:
2007
Tipo del documento:
Article