Intercellular Adhesion Molecule-1 Gene Polymorphism (K469E) in Korean Preeclamptic Women
Journal of Genetic Medicine
; : 105-110, 2008.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-124734
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
Preecalmpsia is a pregnancy-specific disorder that reflects widespread endothelial dysfunction resulting from increases of adhesion molecule expression. Intercellular adhesion molecule-1 (ICAM-1) is involved in the pathogenetic mechanisms responsible for preeclampsia, and ICAM-1 plasma levels and/or function is genetically influenced. Therefore, we evaluated the distribution of ICAM-1 gene K469E polymorphism in pregnant Korean women with preeclampsia and evaluated the association between this polymorphism and preeclampsia.METHODS:
The K469E polymorphism was analyzed in peripheral blood samples from 197 preeclamptic pregnancies and 193 normotensive pregnancies by a SNapShot kit and an ABI Prism 3100 Genetic analyzer.RESULTS:
Genotypic and allelic frequencies of ICAM-1 gene polymorphism (K469E) did not differ between preeclamptic and normotensive pregnancies. The distributions of the KK, KE, and EE genotypes were 40.6%, 43.7%, and 15.7%, respectively, in preeclamptic pregnancies and 38.9%, 45.1%, and 16.1%, respectively, in normotensive pregnancies. The frequencies of K and E alleles were 0.62 and 0.38, respectively, in preeclamptic pregnancies and 0.61 and 0.39, respectively, in normotensive pregnancies. By multiple logistic regression analysis, there was no increased risk of preeclampsia in subjects with ICAM-1 KE (OR, 1.08; P=0.74) or EE (OR, 1.07; P=0.88) genotypes.CONCLUSION:
This study suggests that the ICAM-1 gene K469E polymorphism does not associate with an increased risk of preeclampsia in pregnant Korean women.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Plasma
/
Preeclampsia
/
Modelos Logísticos
/
Molécula 1 de Adhesión Intercelular
/
Alelos
/
Genotipo
Tipo de estudio:
Factores de riesgo
Límite:
Femenino
/
Humanos
/
Embarazo
Idioma:
Inglés
Revista:
Journal of Genetic Medicine
Año:
2008
Tipo del documento:
Artículo