Correlation between Psychopathology and Dopamine Transporter Density in Striatum before and after Taking Olanzapine Assessed with IPT-SPECT in First Episode Schizophrenia / 대한정신약물학회지
Korean Journal of Psychopharmacology
; : 75-83, 2004.
Artículo
en Coreano
| WPRIM (Pacífico Occidental)
| ID: wpr-137193
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE:
Using [123I]IPT-SPECT, we compared between the dopamine transporter (DAT) density of the basal ganglia in first-episode, patients with schizophrenia and DAT density in normal control subjects. We investigated the change between DAT density before and after taking olanzapine during 4weeks in patients with schizophrenia. We studied correlations between the clinical symptoms of schizophrenia and DAT density.METHODS:
Ten patients with schizophrenia and ten healthy control subjects were included in this study. Brief Psychiatric Rating Scale (BPRS) and Montgomery-Asberg Depression Rating Scale (MADRS) were obtained before and after 4-week treatment with olanzapine in schizophrenic group. Nuclear imaging using [123I]IPT-SPECT was obtained in normal control subjects and schizophrenic group before taking olanzapine. After 4-week treatment with olanzapine, Nuclear imaging was obtained in schizophrenic group.RESULTS:
There is significant negative correlation between BPRS total score, withdrawal subscale score after treatment and DAT density before treatment. There is significant positive correlation between the age of onset and DAT density after treatment and there is significant negative correlation between the duration of illness and DAT density after treatment.CONCLUSION:
The data of this study suggest that DAT density in basal ganglia in patients with schizophrenia would be a predicting factor in treatment response.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Escalas de Valoración Psiquiátrica Breve
/
Psicopatología
/
Esquizofrenia
/
Ganglios Basales
/
Dopamina
/
Edad de Inicio
/
Depresión
/
Proteínas de Transporte de Dopamina a través de la Membrana Plasmática
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Psychopharmacology
Año:
2004
Tipo del documento:
Artículo