Recent Advances in Cervical Cancer Vaccine Development / 대한산부인과학회지
Korean Journal of Obstetrics and Gynecology
; : 1377-1389, 2005.
Artículo
en Coreano
| WPRIM (Pacífico Occidental)
| ID: wpr-14113
Biblioteca responsable:
WPRO
ABSTRACT
Human papillomavirus infection is often transient and spontaneously reversible. High-risk human papillomavirus persistence is the major cause of cancerous transformation in several tissues. For prophylactic vaccines there is first clinical evidence of effectivity (ie, 100% protection from HPV infection and dysplasia by virus-like particle (VLP) vaccine-induced neutralizing antibodies). Also, Therapeutic vaccines have entered clinical evaluation. While prophylactic VLP vaccines are immunogenic per se, therapeutic vaccines will need further adjuvants to guide T cell differentiation, expansion, survival, and homing to tumor sites. To enhance clinical outcome of successful T cell induction in patients, the susceptibility of the tumor cells for lysis must be addressed in the future, since tumor immune evasion is a severe problem in cervical cancer. Both preventive and therapeutic human papillomavirus vaccinations will probably change our approach to the screening and therapy of human papillomavirus-related diseases in the next few years. The mass vaccination of adolescent patients should lower the frequency of these very frequently lethal infections.
Texto completo:
Disponible
Contexto en salud:
ODS3 - Salud y Bienestar
Problema de salud:
Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
/
Meta 3.4: Reducir las muertes prematuras por enfermedades no transmisibles
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Vacunas
/
Diferenciación Celular
/
Neoplasias del Cuello Uterino
/
Tamizaje Masivo
/
Vacunación Masiva
/
Vacunación
/
Escape del Tumor
/
Infecciones por Papillomavirus
Tipo de estudio:
Estudio de tamizaje
Límite:
Adolescente
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Obstetrics and Gynecology
Año:
2005
Tipo del documento:
Artículo