Rhabdomyolysis and Acute Kidney Injury Associated with Hypothyroidism and Statin Therapy
Endocrinology and Metabolism
; : 331-334, 2013.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-141174
Biblioteca responsable:
WPRO
ABSTRACT
Rhabdomyolysis is a syndrome involving the breakdown of skeletal muscle that causes myoglobin and other intracellular proteins to leak into the circulatory system, resulting in organ injury including acute kidney injury. We report a case of statin-induced rhabdomyolysis and acute kidney injury that developed in a 63-year-old woman with previously undiagnosed hypothyroidism. Untreated hypothyroidism may have caused her hypercholesterolemia requiring statin treatment, and it is postulated that statin-induced muscle injury was aggravated by hypothyroidism resulting in her full-blown rhabdomyolysis. Although this patient was successfully treated with continuous venovenous hemofiltration and L-thyroxin replacement, rhabdomyolysis with acute kidney injury is a potentially life-threatening disorder. Physicians must pay special attention to the possible presence of subclinical hypothyroidism when administering statins in patients with hypercholesterolemia.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Rabdomiólisis
/
Hemofiltración
/
Músculo Esquelético
/
Inhibidores de Hidroximetilglutaril-CoA Reductasas
/
Lesión Renal Aguda
/
Hipercolesterolemia
/
Hipotiroidismo
/
Músculos
/
Mioglobina
Límite:
Femenino
/
Humanos
Idioma:
Inglés
Revista:
Endocrinology and Metabolism
Año:
2013
Tipo del documento:
Artículo