Low serum bilirubin level predicts the development of chronic kidney disease in patients with type 2 diabetes mellitus
The Korean Journal of Internal Medicine
; : 875-882, 2017.
Article
en En
| WPRIM
| ID: wpr-151262
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND/AIMS: We evaluated whether serum bilirubin levels can predict the development of chronic kidney disease (CKD) in patients with type 2 diabetes mellitus (T2DM). METHODS: This was a retrospective observational longitudinal study of patients presenting at the Pusan National University Hospital. A total of 349 patients with T2DM and preserved kidney function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m²) were enrolled. The main outcome was the development of CKD stage 3 or greater. The patients were divided into four groups according to the quartiles of the total serum bilirubin levels at baseline. RESULTS: The group with the lowest range of total serum bilirubin level (Q1) showed the highest cumulative incidence of CKD stage 3 or greater than that of the other lower quartiles (Q1 vs. Q4; hazard ratio [HR], 6.75; 95% confidence interval [CI], 1.54 to 29.47; p = 0.011). In multivariate analysis, the risk of developing CKD stage 3 or greater was higher in the second lowest quartile of the serum bilirubin level than that in the highest quartile of the serum bilirubin level (Q2 vs. Q4; HR, 9.36; 95% CI, 1.33 to 65.73; p = 0.024). In the normoalbuminuria subgroup (n = 236), multivariate analysis showed that the risk of developing CKD stage 3 or greater was higher in the lowest quartile of the serum bilirubin level than that in the highest quartile of the serum bilirubin level (Q1 vs. Q4; HR, 7.36; 95% CI, 1.24 to 35.82; p = 0.019). CONCLUSIONS: Serum bilirubin might be an early clinical marker for predicting the progression of CKD in patients with T2DM and preserved renal function.
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Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Bilirrubina
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Biomarcadores
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Incidencia
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Análisis Multivariante
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Estudios Retrospectivos
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Estudios Longitudinales
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Diabetes Mellitus Tipo 2
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Nefropatías Diabéticas
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Insuficiencia Renal Crónica
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Tasa de Filtración Glomerular
Tipo de estudio:
Incidence_studies
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Observational_studies
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Prognostic_studies
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Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
The Korean Journal of Internal Medicine
Año:
2017
Tipo del documento:
Article