The relationship between catechol-O-methyltransferase gene polymorphism and coronary artery abnormality in Kawasaki disease / 소아과
Korean Journal of Pediatrics
; : 87-92, 2009.
Artículo
en Coreano
| WPRIM (Pacífico Occidental)
| ID: wpr-153868
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
Many gene polymorphisms are associated with coronary artery abnormalities in Kawasaki disease. Catechol-O-methyltransfe rase (COMT) plays an important role in the metabolism of catecholamines, catechol estrogen, and catechol drugs. Polymorphisms of the COMT gene are reported to be associated with myocardial infarction and coronary artery abnormalities. The aim of this study was to evaluate the relationship between COMT gene polymorphisms and coronary artery abnormalities in Kawasaki disease patients.METHODS:
One hundred and one Korean children with Kawasaki disease and 306 healthy Korean control subjects were enrolled in this study. The polymorphisms of the COMT gene were analyzed by direct sequencing.RESULTS:
There were no differences in the genotype and allelic frequency of the rs4680 and rs769224 polymorphic sites between Kawasaki disease and control subjects. Further, no significant difference was found in the rs4680 polymorphism between patients with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P=0.32, dominant P=0.74, recessive P=0.13). However, the distribution of the rs769224 polymorphism was significantly different between patie nts with coronary artery abnormalities and patients without coronary artery abnormalities (codominant P=0.0077, dominant P=0.0021, recessive P=0.16).CONCLUSION:
Our results indicate that the polymorphisms of the rs769224 gene might be related to the development of coronary artery abnormalities in Kawasaki disease.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Polimorfismo Genético
/
Enfermedad de la Arteria Coronaria
/
Catecolaminas
/
Catecol O-Metiltransferasa
/
Catecoles
/
Vasos Coronarios
/
Estrógenos
/
Genotipo
/
Síndrome Mucocutáneo Linfonodular
/
Infarto del Miocardio
Límite:
Niño
/
Humanos
Idioma:
Coreano
Revista:
Korean Journal of Pediatrics
Año:
2009
Tipo del documento:
Artículo