Low-Grade Inflammation, Metabolic Syndrome and the Risk of Chronic Kidney Disease: the 2005 Korean National Health and Nutrition Examination Survey
Journal of Korean Medical Science
; : 630-635, 2012.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-202336
Biblioteca responsable:
WPRO
ABSTRACT
Either chronic inflammation or metabolic syndrome (MetS) is associated with renal impairment. This cross-sectional study was designed to investigate the relationship between elevated white blood cell (WBC) counts and chronic kidney disease (CKD) stage 3 or more according to the presence of MetS in adult Koreans. In total, 5,291 subjects (> or = 20 yr-old) participating in the 2005 Korean National Health and Nutrition Examination were included. CKD stage 3 or more was defined as having an estimated glomerular filtration rate below 60 mL/min/1.73 m2, as calculated using the formula from the Modification of Diet in Renal Disease study. The odds ratio (95% confidence interval) for CKD stage 3 or more in the highest WBC quartile (> or = 7,200 cells/microL) was 1.70 (1.17-2.39) after adjusting for MetS and other covariates, compared with the lowest WBC quartile (< 5,100 cells/microL). In subjects with MetS, the prevalence risk for CKD stage 3 or more in the highest WBC quartile was 2.25 (1.28-3.95) even after fully adjusting for confounding variables. In contrast, this positive association between WBC quartile and CKD stage 3 or more disappeared in subjects without MetS. Low-grade inflammation is significantly associated with CKD stage 3 or more in subjects with MetS but not in those without MetS.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Índice de Severidad de la Enfermedad
/
Oportunidad Relativa
/
Encuestas Nutricionales
/
Prevalencia
/
Estudios Transversales
/
Factores de Riesgo
/
Síndrome Metabólico
/
República de Corea
/
Tasa de Filtración Glomerular
/
Inflamación
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio de prevalencia
/
Factores de riesgo
Límite:
Adulto
/
Femenino
/
Humanos
/
Masculino
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Journal of Korean Medical Science
Año:
2012
Tipo del documento:
Artículo