The Role of Bile Acid Receptors in Chronic Inflammatory Diseases
Journal of Rheumatic Diseases
; : 253-260, 2017.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-217326
Biblioteca responsable:
WPRO
ABSTRACT
With recent developments, biologic therapies has shown superior efficacy for rheumatic diseases compared with preexisting pharmacologic therapies, which are associated with high costs, non-response in certain patient groups, and severe adverse effects such as infections limiting their wide-spread use and revealing a need for the development of novel treatments. Since discovering the role of bile acid receptors in regulating inflammation, clinical trials evaluating the use of bile acid receptor agonists as a means to potentially treat various inflammatory disorders, such as alcoholic hepatitis, non-alcoholic steatohepatitis, primary biliary cirrhosis, primary sclerosing cholangitis have been ongoing. This review summarizes the results of studies on the anti-inflammatory effects and mechanisms of bile acid receptors and the results of previous to date looking at the use of bile acid receptor agonists in animal models of inflammatory disorders and clinical trials. Furthermore, we present the potentials of the bile acid receptor agonists in the treatment of inflammatory rheumatic diseases, including rheumatoid arthritis.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Artritis Reumatoide
/
Bilis
/
Terapia Biológica
/
Colangitis Esclerosante
/
Enfermedades Reumáticas
/
Modelos Animales
/
Hígado Graso
/
Hepatitis Alcohólica
/
Inflamación
/
Cirrosis Hepática Biliar
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Rheumatic Diseases
Año:
2017
Tipo del documento:
Artículo