Mast Cells and Lipid Mediators
Journal of Bacteriology and Virology
; : 47-51, 2016.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-221987
Biblioteca responsable:
WPRO
ABSTRACT
Human mast cells are potent effector cells in host defense mechanisms of innate and acquired immunity, including inflammatory diseases such as asthma and atherosclerosis. Mast cells originate from pluripotent hematopoietic progenitors in the bone marrow. Activation of mast cells by different stimuli triggers the release of a large range of mediators, including de novo synthesized eicosanoids which are highly biologically active lipid mediators. For the generation of lipid mediators, cytoplasmic lipid droplets have been shown to function as a major intracellular pool of arachidonic acid, the precursor for eicosanoids biosynthesis. The article summarizes current knowledge on mast cell biosynthesis of lipid mediator and the role in inflammation.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Asma
/
Médula Ósea
/
Eicosanoides
/
Ácido Araquidónico
/
Citoplasma
/
Mecanismos de Defensa
/
Aterosclerosis
/
Inmunidad Adaptativa
/
Inflamación
/
Mastocitos
Límite:
Humanos
Idioma:
Inglés
Revista:
Journal of Bacteriology and Virology
Año:
2016
Tipo del documento:
Artículo