Clinical significance and relevant laboratory techniques of detecting azoospermia factors of the Y chromosome / 中华男科学杂志
National Journal of Andrology
; (12): 1117-1120, 2007.
Article
en Zh
| WPRIM
| ID: wpr-232000
Biblioteca responsable:
WPRO
ABSTRACT
Microdeletions of the Y chromosome are a most common known genetic cause of spermatogenetic failure in infertile men. Recent studies have revealed the existence of genetic factors in the long arm of the Y chromosome Yq11.23, known as azoospermia factors (AZF), which are further divided into three separate regions including AZFa, AZFb and AZFc. The AZF deletions are due to different recombination between large palindromic sequences during mesophase. Microdeletions of different AZF regions cause different degrees of spermatogenic impairment. The present paper reviews the clinical significance and relevant laboratory techniques of detecting AZF of the Y chromosome.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Aberraciones Cromosómicas Sexuales
/
Deleción Cromosómica
/
Proteínas de Plasma Seminal
/
Cromosomas Humanos Y
/
Diagnóstico
/
Azoospermia
/
Sitios Genéticos
/
Genética
/
Infertilidad Masculina
Tipo de estudio:
Diagnostic_studies
Límite:
Humans
/
Male
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2007
Tipo del documento:
Article