Progress in research of the structural optimization of natural product-like Garcinia caged xanthones / 药学学报
Acta Pharmaceutica Sinica
; (12): 293-302, 2014.
Article
en Zh
| WPRIM
| ID: wpr-245086
Biblioteca responsable:
WPRO
ABSTRACT
Designing of natural product-like compounds using natural products as template structures is an important strategy for the discovery of new drugs. Gambogic acid (GA), which is a Garcinia natural product with a unique caged xanthone scaffold, inhibits potent antitumor activity both in vitro and in vivo. This review summarized the researches on the identification of the antitumor pharmacophore of GA, and the design, structural optimization and structure-activity relationship (SAR) of natural product-like caged xanthones based on it.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
/
Relación Estructura-Actividad
/
Productos Biológicos
/
Ensayos de Selección de Medicamentos Antitumorales
/
Estructura Molecular
/
Química
/
Garcinia
/
Línea Celular Tumoral
/
Xantonas
/
Proliferación Celular
Límite:
Humans
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2014
Tipo del documento:
Article