Autophagy Activity of CD34+ Cells in MDS Patients and Its Clinical Significance / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 779-783, 2016.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-246868
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To explore the autophagy activity of CD34+ cells in bone marrow of MDS patients and its clinical significance.</p><p><b>METHODS</b>The activity of autophagy in bone marrow CD34+ cells from 20 MDS patients, 20 non-malignant anemia patients and 5 AML patients admitted in our hospital from October 2012 to March 2014 was detected by flow cytometry (FCM).</p><p><b>RESULTS</b>The autophagy activity in low risk MDS patients and non-malignant anemia patients were both significantly higher than that in both high risk MDS and AML patients (P<0.05), and more interestingly, the autophagy activity in MDS negatively correlated with World Health Organization classification-based prognostic system (WPSS) score (r=-0.877) .</p><p><b>CONCLUSION</b>The autophagy activity CD34+ cells in the patients with MDS is higher than that in AML patients, and negatively correlated with WPSS scores, indicating that the decrease of autophagy activity maybe accelerate the genesis and development of MDS and relate with the prognosis of MDS patients.</p>
Texto completo:
Disponible
Contexto en salud:
ODS3 - Salud y Bienestar
Problema de salud:
Meta 3.8: Alcanzar cobertura universal de salud
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Pronóstico
/
Autofagia
/
Síndromes Mielodisplásicos
/
Células de la Médula Ósea
/
Leucemia Mieloide Aguda
/
Antígenos CD34
/
Biología Celular
/
Citometría de Flujo
/
Metabolismo
Tipo de estudio:
Estudio pronóstico
Límite:
Humanos
Idioma:
Chino
Revista:
Journal of Experimental Hematology
Año:
2016
Tipo del documento:
Artículo