Preparation of solid lipid nanoparticles by solvent diffusion method / 药学学报
Acta Pharmaceutica Sinica
; (12): 302-306, 2003.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-251118
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>AIM</b>To establish an efficient method for preparation of solid lipid nanoparticles with high recovery.</p><p><b>METHODS</b>Monostearin solid lipid nanoparticles was prepared by solvent diffusion method in aqueous system. The recovery of the method was greatly improved by adjusting the Zeta potential.</p><p><b>RESULTS</b>The drug-loaded solid lipid nanoparticles suspension was quickly produced and easily separated with centrifugation at 4,000 r.min-1 under acidic condition. Compared with the nanoparticles made without adjusting the Zeta potential, the recovery of nanoparticles prepared in this way was significantly increased. The release behavior in vitro showed an initial burst effect in the first 3 hours followed by a slower rate stage of 4 days with nearly 6% drug released in each day.</p><p><b>CONCLUSION</b>The solvent diffusion method in aqueous system might be used as a new method to prepare solid lipid nanoparticles in the future. The loaded drug can be released in a controlled manner.</p>
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Tamaño de la Partícula
/
Solventes
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Clobetasol
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Portadores de Fármacos
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Química
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Tecnología Farmacéutica
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Sistemas de Liberación de Medicamentos
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Nanotecnología
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Preparaciones de Acción Retardada
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Difusión
Idioma:
Chino
Revista:
Acta Pharmaceutica Sinica
Año:
2003
Tipo del documento:
Artículo