A study on correlation of hepatic metastasis of colorectal cancer to vascular endothelial growth factor, angiopoietin-2, and fibronectin / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
; (12): 20-23, 2005.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-252477
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the correlation of hepatic metastasis of colorectal cancer to vascular endothelial growth factor (VEGF), angiopoietin- 2 and fibronectin (FN).</p><p><b>METHODS</b>The transcription and expression of VEGF, angiopoietin- 2 and FN were detected by semiquantitative reverse transcription- polymerase chain reaction (SQRT- PCR) and immunohistochemical staining in the specimens from sixty patients with colorectal cancer.</p><p><b>RESULTS</b>The mRNA transcription and expression levels of VEGF, angiopoietin- 2 and FN in colorectal cancer tissues were obviously higher than those in paratumor normal tissues P< 0.05. The transcription and expression levels of VEGF were correlated with tumor invasion P< 0.05,Dukes' stage P< 0.05,and lymph node and/or hepatic metastasis P< 0.05. Angiopoietin expression and transcription levels were correlated with tumor differentiation. The expression of FN in extra cellular matrix (ECM) was significantly higher (P< 0.05),whereas ECM in basement membrane was significantly lower in cancer tissues than that in paratumor normal tissues (P< 0.05),which both were correlated with tumor invasion P< 0.05,Dukes' stage P< 0.05,and lymph node metastasis P< 0.05. Absence of FN protein in basement membrane was also correlated with hepatic metastasis.</p><p><b>CONCLUSION</b>Colorectal cancer cells can secrete VEGF and contribute to metastasis and proliferation of tumor by stimulating the growth of tumor vessel. Both of VEGF and angiopoietin- 2 contribute to angiogenesis and the decrease of FN in basement membrane of cancer tissue is an important primary factor of hepatic metastasis.</p>
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
ARN Mensajero
/
Neoplasias Colorrectales
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Estudios de Casos y Controles
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Fibronectinas
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Angiopoyetina 2
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Factor A de Crecimiento Endotelial Vascular
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Neoplasias Hepáticas
/
Metabolismo
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Metástasis de la Neoplasia
Tipo de estudio:
Estudio observacional
Límite:
Adulto
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Anciano
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Anciano de 80 o más años
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Gastrointestinal Surgery
Año:
2005
Tipo del documento:
Artículo