Alkaloids from the root of Lindera angustifolia / 药学学报

ABSTRACT

<p><b>AIM</b>To study the alkaloid constituents of the root of Lindera angustifolia Cheng.</p><p><b>METHODS</b>The constituents were isolated and purified by column chromatography and the structures were characterized by spectral analysis.</p><p><b>RESULTS</b>Seven aporphine alkaloids, laurotetanine (I), N-methyllaurotetanine (II), boldine (III), isoboldine (IV), norboldine (V), N-ethoxycarbonyllaurotetanine (VII) and a quaternary isoquinoline alkaloid, magnocurarine (VI), were isolated and identified. The structure of VII was further identified by semi-synthesis with I as starting material.</p><p><b>CONCLUSION</b>All compounds were obtained from this plant for the first time and compound VII was found as a naturally occurring compound for the first time.</p>