Clinical trial on ibandronate in patients with tumor-associated hypercalcemia / 中华肿瘤杂志
Chinese Journal of Oncology
; (12): 739-741, 2004.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-254257
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>Ibandronate, a third generation bisphosphonate, inhibits bone resorption in human and animal studies. This study is to evaluate the efficacy and safety of ibandronate as a single agent in patients with tumor-associated hypercalcemia.</p><p><b>METHODS</b>An open, multicenter, non-controlled clinical trial was conducted in 22 patients. The patients received 2 mg ibandronate intravenously if the corrected calcium was less than 3.0 mmol/L but more than 2.7 mmol/L; they received 4 mg ibandronate iv if corrected calcium was more than 3.0 mmol/L.</p><p><b>RESULTS</b>There was 100% efficacy in these two dose groups but the calcium correcting effect was more pronounced in the 4-mg dose group than the 2-mg dose group. The most common adverse reactions were fever and skin itching with an incidence of 4.5%.</p><p><b>CONCLUSION</b>Ibandronate is active in patients with tumor-associated hypercalcemia and the adverse effects are well tolerated.</p>
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Patología
/
Fósforo
/
Prurito
/
Sangre
/
Neoplasias Óseas
/
Neoplasias de la Mama
/
Esquema de Medicación
/
Calcio
/
Secreciones Corporales
/
Usos Terapéuticos
Tipo de estudio:
Ensayo clínico controlado
Límite:
Femenino
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
Chinese Journal of Oncology
Año:
2004
Tipo del documento:
Artículo