Clinical Characteristics of Type 1 Diabetes Mellitus at Initial Diagnosis / 대한소아내분비학회지
Journal of Korean Society of Pediatric Endocrinology
; : 177-184, 2006.
Artículo
en Coreano
| WPRIM (Pacífico Occidental)
| ID: wpr-26284
Biblioteca responsable:
WPRO
ABSTRACT
PURPOSE:
The incidence of type 1 diabetes mellitus is increasing worldwide, the complications such as growth impairment, thyroid dysfunction, microvascular disease can be accompanied in type 1 diabetes mellitus. So, it is important to study initial clinical characteristics of type 1 diabetes mellitus for long-term managements of such complications.METHODS:
Forty children and adolescents with type 1 diabetes mellitus who had been followed up in the department of pediatrics, Ajou university hospital from December 1997 to June 2006 were enrolled in this study. Sex, Onset Age, onset season, body mass index, family history, serum blood glucose, urine ketone, admission duration, HbA1c, serum and 24 hours urine C-peptide, islet cell antibody, daily insulin dose, insulin like growth factor-I, thyroid function test, lipid profile, bone age of patients were reviewed retrospectively.RESULTS:
Forty patients were enrolled19 boys and 21 girls. The mean age of diagnosis was 9.2+/-3.5 years. There were no seasonal variation in onset time. The body mass index were 15.9+/-2.7 kg/m2. In family history, 1 patient had type 1 and 16 patients (40%) had type 2 diabetes. Blood glucose was 509+/-172 mg/dL. Urine ketone was positive in 77.8% of patients. HbA1c was 12.5+/-2.4%. Serum C-peptide was 0.76+/-0.65 ng/mL and there was statistically significant positive relationship between patient's age and serum C-peptide level (P<0.05). Daily insulin dose was 0.89+/-0.28 unit/kg/day and negatively correlated with serum C-peptide level (P<0.05), but there were no differences in daily insulin dose between prepubertal and pubertal patients. In 82.4% of patients, at least one of 3 antibody (glutamic acid decarboxylase antibody, islet cell antibody, insulin auto antibody) were detected. Serum C-peptide were higher in GAD Ab positive group than in negative group (P<0.05). In 63.6% of patients, Insulin like growth factor-I levels were lower than normal control group. Thyroid dysfunction were found in 7.5% of patients. 48.7% of patients were accompanied with dyslipidemia. In 51.9% of patients, bone age was advanced by at least 6 months.CONCLUSION:
For the most part, our results were consistent with previous studies. But some points like, 1) there was no seasonal variation in onset time, 2) serum C-peptide was not low, 3) there were no differences in daily insulin dose between prepubertal and pubertal patients, differed from previous studies.
Texto completo:
Disponible
Contexto en salud:
ODS3 - Salud y Bienestar
/
ODS3 - Meta 3.4 Reducir las muertes prematuras por enfermedades no transmisibles
/
ODS3 - Meta 3.2 Evitar muertes en recién nacidos y niños menores de 5 años
Problema de salud:
Meta 3.2: Evitar muertes en recién nacidos y niños menores de 5 años
/
Diabetes Mellitus
/
Enfermedades del Sistema Endocrino
/
Obesidad
/
Enfermedades No Transmisibles
/
Nutrición
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Pediatría
/
Estaciones del Año
/
Pruebas de Función de la Tiroides
/
Glándula Tiroides
/
Glucemia
/
Péptido C
/
Índice de Masa Corporal
/
Incidencia
/
Estudios Retrospectivos
/
Islotes Pancreáticos
Tipo de estudio:
Estudio diagnóstico
/
Estudio de incidencia
/
Estudio observacional
/
Estudio pronóstico
Límite:
Adolescente
/
Niño
/
Femenino
/
Humanos
Idioma:
Coreano
Revista:
Journal of Korean Society of Pediatric Endocrinology
Año:
2006
Tipo del documento:
Artículo