Design, synthesis and insulin-sensitizing activity of indole derivatives / 药学学报

ABSTRACT

<p><b>AIM</b>To design and synthesize compounds with insulin-sensitizing activity.</p><p><b>METHODS</b>Using association principle of drug design, ten title compounds were designed and synthesized on the basis of known compounds with insulin-sensitizing activity, and their insulin-sensitizing activity were evaluated on 3T3-L1 pre-adipocyte cells.</p><p><b>RESULTS</b>One of the synthesized compounds showed strong insulin-sensitizing activity in vitro.</p><p><b>CONCLUSION</b>This compound may possess good sugar-lowering activity, and will be chosen for further hypoglycemic evaluation in vivo.</p>