A Case of Tuberous Sclerosis with Subependymal Giant Cell Astrocytoma (SEGA) Treated with Gamma Knife Surgery / 대한소아신경학회지
Journal of the Korean Child Neurology Society
; (4): 195-199, 2013.
Article
en Ko
| WPRIM
| ID: wpr-27419
Biblioteca responsable:
WPRO
ABSTRACT
Subependymal giant cell astrocytoma (SEGA) is the most common brain tumor that develops in 5-20% of patients with tuberous sclerosis complex. Although these lesions are slowly growing tumor, they can cause morbidity and mortality due to acute hydrocephalus because of their prevalent location near the foramen of Monro. Surgery has been the standard care for SEGAs demonstrating serial growth and symptomatic hydrocephalus. However, not all SEGAs are treatable by complete surgical resection. Gamma Knife stereotactic radiosurgery can be considered as a second option, but it has shown highly variable responses in patients with limited data. In recent years, drugs with novel mechanism, sirolimus and other mammalian target of rapamycin (mTOR) inhibitors have been found to reduce the size of SEGAs. We report a case of treatment of SEGA with gamma knife surgery which continued for two years without progression, even though surgical resection was done, finally.
Palabras clave
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Astrocitoma
/
Esclerosis Tuberosa
/
Neoplasias Encefálicas
/
Ventrículos Cerebrales
/
Mortalidad
/
Radiocirugia
/
Sirolimus
/
Hidrocefalia
Tipo de estudio:
Prognostic_studies
Límite:
Humans
Idioma:
Ko
Revista:
Journal of the Korean Child Neurology Society
Año:
2013
Tipo del documento:
Article