Enhanced absorption of breviscapine photosomes in small intestine of rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate whether the absorption of breviscapine can be enhanced by using breviscapine photosomes.</p><p><b>METHOD</b>Testing the uptake and intestinal permeability of breviscapine powder and breviscapine photosomes by using intestine perfusion technique and reverted gut sac method.</p><p><b>RESULT</b>The uptake and permeability coefficient of breviscapine were increased in photosomes. The absorption process obeyed the Fick's law in the range of 0-100 microg x mL(-1).</p><p><b>CONCLUSION</b>The absorption breviscapine photosomes is enhanced by increasing the permeability through a passive mechanism.</p>