Lowered lipids efficiency of compound red yeast rice extract in rats with hyperlipidemia / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 504-507, 2010.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-280986
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effects of compound red yeast rice extract (CRYRE) on blood lipids, hemorheology and blood coagulant system in rats with hyperlipidemia.</p><p><b>METHOD</b>SD rats were randomly divided into six groups normal control group, model group, Xuezhikang group (0. 24 g x kg(-1)), CRYRE high dose group (2.4 g x kg(-1)), middle dose group (1.2 g x kg(-1)) and low dose group (0.6 g x kg(-1)). The normal control rats were given pure water, and rats of other five groups were given 10 mL kg lipid emulsion and subjected to daily intragastric administration simultaneously in two days, continuously for 3 weeks. After the last medication, all the rats were sacrificed for measurement of blood lipids, hemorheology and coagulation factors.</p><p><b>RESULT</b>CRYRE 2.4 g x kg(-1) could significantly reduce the serum TG, TC levels and increase the HDL-C level (P < 0.01, P < 0.05). CRYRE 0.6-2.4 g x kg(-1) could significantly increase the ratios of HDL-C/TG,HDL-C/TC and HDL-C/LDL-C (P < 0.01). CRYRE 2.4 g x kg(-1) also reduced whole blood viscosity and plasma viscosity (P < 0.01, P < 0.05), prolonged active partial thromboplastin time, and lowered fibrinogen content (P < 0.01, P < 0.05).</p><p><b>CONCLUSION</b>CRYRE 2.4 g x kg(-1) could reduce blood lipids, blood viscosity and fibrinogen content, improve blood circulation, and depress the alteration of blood coagulant system resulted from lipid metabolic disorder in rats with hyperlipidemia.</p>
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Productos Biológicos
/
Sangre
/
Circulación Sanguínea
/
Distribución Aleatoria
/
Química
/
Ratas Sprague-Dawley
/
Modelos Animales de Enfermedad
/
Quimioterapia
/
Hiperlipidemias
/
Lípidos
Tipo de estudio:
Ensayo clínico controlado
/
Estudio pronóstico
Límite:
Animales
/
Humanos
/
Masculino
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2010
Tipo del documento:
Artículo