Protective effect of curcumin on experimental liver injury in mice / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 756-793, 2003.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-282247
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To Study the protective effect of curcumin on three models of experimental liver injury in mice.</p><p><b>METHOD</b>The experimental models of live injury were induced by carbon tetrachloride (CCl4), D-galactosamine (D-Gal N), and Bacillus Calmette-Guerin (BCG) Plus lipolysaccharides (LPS), respectively, in mice. The serum ALT, AST, NO and liver MDA were measured to evaluate the protective effect of curcumin on experimental injury in mice.</p><p><b>RESULT</b>Curcumin (50 mg.kg-1, 100 mg.kg-1, 150 mg.kg-1), like biophenyldicarboxylate, were shown to significantly inhibit the increase of serum ALT, AST, NO and liver molondialdehyde (MDA) content induced by CCl4, D-Gal N, BCG + LPS.</p><p><b>CONCLUSION</b>Curcumin showed protective effect against liver injury induced by CCl4, D-Gal N, BCG plus LPS.</p>
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Aspartato Aminotransferasas
/
Sangre
/
Intoxicación por Tetracloruro de Carbono
/
Lipopolisacáridos
/
Sustancias Protectoras
/
Curcumina
/
Alanina Transaminasa
/
Enfermedad Hepática Inducida por Sustancias y Drogas
/
Galactosamina
Límite:
Animales
Idioma:
Chino
Revista:
China Journal of Chinese Materia Medica
Año:
2003
Tipo del documento:
Artículo