Pharmacokinetic study of intraperitoneal chemotherapy with HCPT / 中国中药杂志
China Journal of Chinese Materia Medica
; (24): 1610-1612, 2005.
Article
en Zh
| WPRIM
| ID: wpr-287326
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the pharmacokinetic of 10-Hydroxycamptothecin HCPT by intraperitoneal administration.</p><p><b>METHOD</b>Six dogs were given HCPT by intraperitoneal perfusion: HCPT 2 mg x kg(-1), dissolved in 300 mL NS. During the course of experiments, peritoneal fluids and blood were sampled using a standardized protocol. The concentration of HCPT in all samples was determined by high performance liquid chromatography (HPLC).</p><p><b>RESULT</b>The area under the curve (AUC) of peritoneal fluids was significantly highly as compared to the AUC of femoral vein and portal vein (P < 0.001).</p><p><b>CONCLUSION</b>These experiments demonstrate that intraperitoneal chemotherapy has significant effect on the pharmacokinetics of IP route of HCPT administration. This method should be a more reasonable chemotherapy for the prevention of recurrence and liver metastasis of gastric cancer, colon cancer and ovary cancer after radical resection.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Camptotecina
/
Líquido Ascítico
/
Farmacocinética
/
Área Bajo la Curva
/
Infusiones Parenterales
/
Metabolismo
/
Antineoplásicos Fitogénicos
Tipo de estudio:
Prognostic_studies
Límite:
Animals
Idioma:
Zh
Revista:
China Journal of Chinese Materia Medica
Año:
2005
Tipo del documento:
Article