Predicting Factors for Refractory Kawasaki Disease
Korean Circulation Journal
; : 239-242, 2010.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-28915
Biblioteca responsable:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES:
About 10-15% of Kawasaki disease (KD) is refractory to intravenous immunoglobulin (IVIG) therapy. This study was designed to investigate the predicting factors for refractory KD. SUBJECTS ANDMETHODS:
We reviewed retrospectively the clinical records of 77 patients with typical KD admitted at Wonju Christian Hospital from January, 2005, to December, 2008. The variance of laboratory and demographic parameters between the IVIG-responsive group and IVIG-resistant group were analyzed. Thirteen patients with urinary tract infections were randomly collected as a febrile control group.RESULTS:
Among 77 patients diagnosed with complete KD, 13 patients (16.9%) were IVIG-resistant. The febrile period and hospital days were significantly longer in the IVIG-resistant group than IVIG-responsive group (p<0.001, p=0.002). Serum levels of albumin and sodium were significantly lower in the IVIG-resistant group (p=0.025). The Kobayashi score could differentiate these two groups (p=0.015). Fewer lymphocytes was observed during the subacute phase in the IVIG-resistant group (p=0.032). Coronary arterial dilatations (CADs) were observed in 10.9% (7/64) of IVIG-responders and 38.5% (5/13) of IVIG-resistant patients (p=0.038).CONCLUSION:
The percentage of neutrophils and lymphocytes in patients with KD, in addition to known risk factors for refractory KD, may help predict IVIG-resistance in patients with KD.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Sodio
/
Infecciones Urinarias
/
Inmunoglobulinas
/
Linfocitos
/
Estudios Retrospectivos
/
Factores de Riesgo
/
Vasos Coronarios
/
Dilatación
/
Síndrome Mucocutáneo Linfonodular
/
Neutrófilos
Tipo de estudio:
Estudio de etiología
/
Estudio observacional
/
Estudio pronóstico
/
Factores de riesgo
Límite:
Humanos
Idioma:
Inglés
Revista:
Korean Circulation Journal
Año:
2010
Tipo del documento:
Artículo