Yttrium-90 Selective Internal Radiation Therapy with Glass Microspheres for Hepatocellular Carcinoma: Current and Updated Literature Review
Korean Journal of Radiology
; : 472-488, 2016.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-29168
Biblioteca responsable:
WPRO
ABSTRACT
Hepatocellular carcinoma is the most common primary liver cancer and it represents the majority of cancer-related deaths in the world. More than 70% of patients present at an advanced stage, beyond potentially curative options. Ytrrium-90 selective internal radiation therapy (Y90-SIRT) with glass microspheres is rapidly gaining acceptance as a potential therapy for intermediate and advanced stage primary hepatocellular carcinoma and liver metastases. The technique involves delivery of Y90 infused glass microspheres via the hepatic arterial blood flow to the appropriate tumor. The liver tumor receives a highly concentrated radiation dose while sparing the healthy liver parenchyma due to its preferential blood supply from portal venous blood. There are two commercially available devices TheraSphere® and SIR-Spheres®. Although, Y90-SIRT with glass microspheres improves median survival in patients with intermediate and advanced hepatocellular carcinoma and has the potential to downstage hepatocellular carcinoma so that the selected candidates meet the transplantable criteria, it has not gained widespread acceptance due to the lack of large randomized controlled trials. Currently, there are various clinical trials investigating the use of Y90-SIRT with glass microspheres for treatment of hepatocellular carcinoma and the outcomes of these trials may result in the incorporation of Y90-SIRT with glass microspheres into the treatment guidelines as a standard therapy option for patients with intermediate and advanced stage hepatocellular carcinoma.
Texto completo:
Disponible
Contexto en salud:
ODS3 - Meta 3.4 Reducir las muertes prematuras por enfermedades no transmisibles
Problema de salud:
Enfermedades del Sistema Digestivo
/
Neoplasia Hepática
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Carcinoma Hepatocelular
/
Vidrio
/
Hígado
/
Neoplasias Hepáticas
/
Microesferas
/
Metástasis de la Neoplasia
Tipo de estudio:
Ensayo clínico controlado
/
Guía de práctica clínica
Límite:
Humanos
Idioma:
Inglés
Revista:
Korean Journal of Radiology
Año:
2016
Tipo del documento:
Artículo