Protective immunity induced by the anti-idiotypic monoclonal antibody NP30 of Schistosoma japonicum / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 576-579, 2002.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-302248
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the protective immunity induced by the anti-idiotypic monoclonal antibody NP30 of Schistosoma japonicum in mice.</p><p><b>METHODS</b>An orthogonal table L(16) (4 x 2(12)) was selected as the experimental design. Eight-week-old Kunming outbred mice (male and female) were randomly divided into 16 experimental groups and 2 control groups. Control groups were injected with SP2/0 ascites intraperitoneally. Mice from each group were infected with 100 +/- 2 cercariae of Schistosoma japonicum in the abdominal skin and were sacrificed on the thirtieth day postchallenge. Adult worms were recovered and counted by perfusion of the left ventricle-portal vein. The SP2/0 ascites injected mice were used as controls and the percentage of protection was calculated.</p><p><b>RESULTS</b>Active immunization of mice with NP30 could produce protection levels ranging from 22.36% to 50.46% depending on the different immunity protocols. The best immunization protocol was established from the results.</p><p><b>CONCLUSIONS</b>Active immunization with NP30 can induce a degree of protection to infection with Schistosoma japonicum cercariae and NP30 is a potential vaccine candidate against Schistosoma japonicum.</p>
Texto completo:
Disponible
Contexto en salud:
ODS3 - Salud y Bienestar
/
Enfermedades Desatendidas
Problema de salud:
Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
/
Enfermedades Desatendidas
/
Zoonosis
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Parasitología
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Schistosoma mansoni
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Esquistosomiasis mansoni
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Anticuerpos Antiidiotipos
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Análisis de Varianza
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Vacunación
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Resultado del Tratamiento
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Animales no Consanguíneos
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Usos Terapéuticos
/
Alergia e Inmunología
Límite:
Animales
Idioma:
Inglés
Revista:
Chinese Medical Journal
Año:
2002
Tipo del documento:
Artículo