Clinical and histological characteristics of chronic hepatitis B with negative hepatitis B e-antigen / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1312-1317, 2003.
Article
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| WPRIM
| ID: wpr-311692
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To study the clinical and histological features of chronic hepatitis B (CHB) with negative hepatitis B e-antigen (HBeAg).</p><p><b>METHODS</b>A total of 743 in-patients with chronic hepatitis B were recruited into the study and divided into two groups according to the HBeAg status. The correlation among alanine transaminase (ALT) levels, hepatitis B virus (HBV) DNA semiquantification, and the liver histopathological data were detected.</p><p><b>RESULTS</b>Of the 743 successive in-patients, 267 (35.9%) were HBeAg-negative. The HBDAG-negative group had significantly lower serologic HBV DNA levels (63.0% of < 100 pg/ml) vs HBeAg-positive (42.6%, P < 0.001), while more sever inflammation (58.1% of inflammatory scores of histological activity index (HAIinf > or = 9) vs HBeAg-positive group (46.0%, P < 0.001) and severe fibrosis (45.3% of fibrosis scores of histological activity index (HAIfib > or = 3) vs HBeAg-positive group (27.9%, P < 0.001) of liver histology. In HBeAg-positive patients, increasing ALI levels were significantly associated with high inflammation and fibrosis scores and low HBV DNA levels. However, it was not the case in the HBeAg-negative cases. In HBeAg-positive patients, 91.3% of them had HAIinf > or = 9 and 65.7% had HAIfib > or = 3 with HBV DNA > 100 pg/ml, while 8.2% of them had HAIinf > or = 9 and 12.3% had HAIfib > or = 3 with HBV DNA < 20 pg/ml, indicating an obverse correlation between HBV DNA levels and histology scores.</p><p><b>CONCLUSIONS</b>As regards clinical and histological background, the chronic HBeAg-negative hepatitis B is a different subpopulation from the HBeAg-positive counterpart.</p>
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Base de datos:
WPRIM
Asunto principal:
Patología
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Fibrosis
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ADN Viral
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Virus de la Hepatitis B
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Alergia e Inmunología
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Genética
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Hepatitis B
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Antígenos e de la Hepatitis B
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Hepatitis Crónica
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Hígado
Límite:
Humans
Idioma:
En
Revista:
Chinese Medical Journal
Año:
2003
Tipo del documento:
Article