Synthesis and characterization of thermosensitive hydrogel based on PEG-PCL-PEG block copolymers / 生物医学工程学杂志
Journal of Biomedical Engineering
; (6): 1121-1125, 2008.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-318201
Biblioteca responsable:
WPRO
ABSTRACT
In this paper, a series of low-molecular-weight PEG-PCL-PEG triblock copolymers were successfully synthesized by ring-opening polymerization method, and were characterized using 1H-NMR and FTIR. The aqueous solution displayed specific thermosensitive gel-sol transition when the concentration was above corresponding critical gel concentration (CGC). The gel-sol phase diagram was recorded using test tube-inverting method, which was depended on the hydrophilic/hydrophobic balance in macromolecular structure, as well as heating history. As a result, the gel-sol transition temperature range could be altered, which might be very useful for its application as injectable drug delivery system.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Poliésteres
/
Polietilenglicoles
/
Temperatura
/
Materiales Biocompatibles
/
Portadores de Fármacos
/
Química
/
Sistemas de Liberación de Medicamentos
/
Espectroscopía Infrarroja por Transformada de Fourier
/
Hidrogel de Polietilenoglicol-Dimetacrilato
Idioma:
Chino
Revista:
Journal of Biomedical Engineering
Año:
2008
Tipo del documento:
Artículo