Expressions of c-mpl proteins on CD34+ bone marrow cells and platelets of the patients with polycythemia vera / 中国实验血液学杂志
Journal of Experimental Hematology
; (6): 1061-1064, 2007.
Article
en Zh
| WPRIM
| ID: wpr-318789
Biblioteca responsable:
WPRO
ABSTRACT
The objective of this study was to investigate the expressions of TPO receptor (c-mpl) proteins on CD34 positive bone marrow cells (CD34+ BMCs), platelets and the expression of c-mpl mRNA in bone marrow cells of the patients with polycythemia vera (PV). The expressions of c-mpl proteins on CD34+ bone marrow hematopoietic cells of 13 PV patients and 15 normal controls were assessed by bicolor flow cytometry and the expressions of c-mpl proteins on platelets of 15 PV patients and 15 normal controls were assessed by monocolor flow cytometry, and the expressions of c-mpl mRNA in bone marrow hematopoietic cells (BMHCs) were assessed by RT-PCR. The results showed that no difference was found between the expression of c-mpl proteins on CD34+ BMHCs of PV patients (0.99% +/- 0.14%) and that of normal controls (0.92% +/- 0.12%) (p > 0.05). There was no difference too between the expression of c-mpl protein on platelets in PV patients (20.33% +/- 4.84%) and that in normal controls (23.50% +/- 3.64%) (p > 0.05). No difference between the expression of c-mpl mRNA in BMHCs of PV patients and that in normal controls was seen. In conclusion, the expressions of c-mpl proteins on CD34+ BMHCs, platelets and c-mpl mRNA in BMHCs of PV patients were not obviously abnormal.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
/
Policitemia Vera
/
Plaquetas
/
ARN Mensajero
/
Células de la Médula Ósea
/
Células Madre Hematopoyéticas
/
Antígenos CD34
/
Receptores de Trombopoyetina
/
Genética
/
Metabolismo
Límite:
Humans
Idioma:
Zh
Revista:
Journal of Experimental Hematology
Año:
2007
Tipo del documento:
Article