Effect of tumor necrosis factor-alpha on differentiation of mesencephalic neural stem cells and proliferation of oligodendrocytes in the rat / 生理学报
Acta Physiologica Sinica
; (6): 183-186, 2003.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-318920
Biblioteca responsable:
WPRO
ABSTRACT
To observe the influence of tumor necrosis factor-alpha (TNF-alpha) on differentiation of rat mesencephalic neural stem cells (NSCs), the numbers of neurons, astrocytes and oligodendrocytes generated from NSCs were analyzed after differentiation for 3 days by using immunocytochemistry technique. The results show that (1) TNF-alpha enhanced the proportions of neurons and oligodendrocytes in progeny of NSCs; and (2) TNF-alpha induced the proliferation of oligodendrocytes derived from NSCs, but the proliferation of astrocytes was not influenced by TNF-alpha. We conclude that the TNF-alpha could influence the application of NSCs.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Fisiología
/
Mesencéfalo
/
Diferenciación Celular
/
Oligodendroglía
/
Astrocitos
/
Factor de Necrosis Tumoral alfa
/
Ratas Sprague-Dawley
/
Biología Celular
/
Proliferación Celular
/
Células-Madre Neurales
Límite:
Animales
Idioma:
Chino
Revista:
Acta Physiologica Sinica
Año:
2003
Tipo del documento:
Artículo