Study on the relationship of balanced translocation t(1;12) with spermatogenesis / 中华男科学杂志
National Journal of Andrology
; (12): 247-249, 2002.
Article
en Zh
| WPRIM
| ID: wpr-322603
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVES</b>To investigate the relationship between chromosome balanced translocation t(1;12) (q24;q24) and spermatogenesis in infertile twin brothers.</p><p><b>METHODS</b>For twin brothers, karotype were determined. The levels of testosterone, FSH and LH were detected. YRRM1, DAZ and DYS240 were analyzed. In younger brother a biopsy was taken from testis.</p><p><b>RESULTS</b>Chromosome analysis for both twin brothers revealed a karotype of 46, XY, t(1;12) (q24;q24). Sperm count was less than 1.0 x 10(6)/ml. There was no deletion for YRRM1, DAZ and DYS240 gene on Y chromosome. Photomicrograph of seminiferous tubules showed the arrest of spermatogenesis.</p><p><b>CONCLUSIONS</b>Chromosome balanced translocation t(1;12) (q24;q24) may be the cause of the spermatogenesis arrest in infertile twin brothers. Gene in the point of translocation may be related to spermatogenesis.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
/
Espermatogénesis
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Testículo
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Translocación Genética
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Biopsia
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Cromosomas Humanos Par 1
/
Cromosomas Humanos Par 12
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Enfermedades en Gemelos
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Genética
/
Infertilidad Masculina
Límite:
Adult
/
Humans
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Male
Idioma:
Zh
Revista:
National Journal of Andrology
Año:
2002
Tipo del documento:
Article