Serum levels of IgG subclasses and vitamin A in children with recurrent respiratory tract infection / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
; (12): 557-558, 2007.
Article
en Zh
| WPRIM
| ID: wpr-325672
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>The development of recurrent respiratory tract infection (RRTI) is related to vitamin A deficiency and immune function abnormality in children. This study examined serum levels of IgG subclasses and vitamin A in children with recurrent respiratory tract infection.</p><p><b>METHODS</b>Serum IgG subclasses levels (IgG1, IgG2, IgG3, IgG4) were detected using ELISA and serum vitamin A levels were detected using high performance liquid chromatography-Miller method in 80 children with RRTI (ranged from 2-10 years old). The values were compared with those from 80 aged-matched healthy children.</p><p><b>RESULTS</b>Serum levels of IgG2 (1.52 +/- 0.18 g/L) and IgG4 (0.22 +/- 0.12 g/L) in children with RRTI were significantly lower than controls (IgG2: 2.23 +/- 0.08 g/L; IgG4: 0.28 +/- 0.01 g/L) (P < 0.05). Serum vitamin A levels in children with RRTI were also significantly lower than controls (1.16 +/- 0.22 micromol/L vs 1.56 +/- 0.12 micromol/L; P < 0.05). IgG2 and IgG4 deficiency (27%) was the most common in 22 RRTI children with vitamin A deficiency.</p><p><b>CONCLUSIONS</b>Serum levels of IgG subclasses, IgG2 and IgG4, and vitamin A decrease in children with RRTI. There might be some relationship between the decreased IgG2 and IgG4 levels and vitamin A deficiency.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Infecciones del Sistema Respiratorio
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Vitamina A
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Sangre
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Inmunoglobulina G
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Clasificación
Límite:
Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Contemporary Pediatrics
Año:
2007
Tipo del documento:
Article