The clinical features of B cell lymphoblastic lymphoma and outcomes after BFM-90 regimen therapy / 中华血液学杂志
Chinese Journal of Hematology
; (12): 649-652, 2006.
Article
en Zh
| WPRIM
| ID: wpr-328407
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To analyse the clinical features of patients with B cell lymphoblastic lymphoma(BCLL) and the outcomes after modified BFM-90 protocol therapy.</p><p><b>METHODS</b>The clinical features of 14 patients with BCLL were analysed, and compared with that of T cell lymphoblastic lymphoma in the same period. The efficacy and toxicity of modified BFM-90 protocol were analysed.</p><p><b>RESULTS</b>The 14 patients were aged 3 to 18 and diagnosed as BCLL by morphology and immunohistology. One case was in stage I , 2 stage III and 11 stage IV. Most common involved sites were lymph nodes (70% ), skin (50% ) and bone marrow (64% ). One patient received CHOP + HD-MTX, and 13 received modified BFM-90 protocol chemotherapy. Twelve patients (92.3%) achieved complete remission( CR) , 1 patient(7. 7% ) partial remission( PR). The median follow-up duration was 19. 5 months (2 to 44 months). At present 13 patients are alive except one PR patient who gave up treatment and died of disease. The major toxicity of the protocol was myelosuppression, but could be tolerated.</p><p><b>CONCLUSIONS</b>The most common involvement sites of BCLL were lymph nodes, skin and bone marrow. The effectiveness is improved as treated with modified BFM-90 protocol.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Esquema de Medicación
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Protocolos de Quimioterapia Combinada Antineoplásica
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Metotrexato
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Estudios de Seguimiento
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Linfoma de Células B
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Resultado del Tratamiento
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Usos Terapéuticos
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Quimioterapia
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Leucemia-Linfoma Linfoblástico de Células Precursoras
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Mercaptopurina
Tipo de estudio:
Guideline
/
Observational_studies
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Prognostic_studies
Límite:
Adolescent
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Child
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Child, preschool
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Female
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Humans
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Male
Idioma:
Zh
Revista:
Chinese Journal of Hematology
Año:
2006
Tipo del documento:
Article