Relationship between hepatitis B virus genotypes and liver fibrosis / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To study the relationship between hepatitis B virus (HBV) genotypes and liver fibrosis.</p><p><b>METHODS</b>Polymerase chain reaction-restriction fragment length polymorphism method was employed to determine HBV genotypes in 298 HBV-related liver disease patients, including 73 with hepatocellular carcinoma, 53 with liver cirrhosis, 91 with chronic hepatitis B and 82 asymptomatic HBV carriers to analyze the relationship of HBV genotypes with serum fibrous indices and serum albumin and globulin (A/G) ratio.</p><p><b>RESULTS</b>B and C genotypes were dominant in patients with HBV-related hepatic diseases in Guangdong province. The levels of serum fibrous indices were significantly higher in patients with genotype C than in those with genotype B, and the former patients also had lower A/G ratio.</p><p><b>CONCLUSION</b>Patients with HBV genotype C may sustain more serious liver injury.</p>