Changes of amino acids neurotransmitters in striatum of hemi-parkinsonian rhesus monkey after high frequency stimulation of subthalamic nucleus / 中华外科杂志
Chinese Journal of Surgery
; (12): 1682-1684, 2007.
Article
en Zh
| WPRIM
| ID: wpr-338089
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of high frequency stimulation of the subthalamic nucleus on the levels of amino acids neurotransmitters in striatum of hemi-parkinsonian monkeys.</p><p><b>METHODS</b>Two rhesus monkeys were successfully prepared for the subsequent microdialysis sessions. Collecting the dialysate before turning on the pulse generator, and collecting at 1 week, 1, 8 and 12 months after high frequency stimulation of the subthalamic nucleus. The level of Glu, GABA and Tau were determined by high performance liquid chromatography and fluorometric detection (HPLC-FD).</p><p><b>RESULTS</b>After high frequency stimulation (HFS), PD symptoms of monkeys significantly improved. The levels of Glu in putamen and caudate nucleus of electrodes side at 1 week, 1, 8 and 12 months were increased significantly. The levels of GABA in putamen and caudate nucleus of electrodes side at 1 week, 1 month increased significantly compared with before turning on the pulse generator while decreased at 8, 12 months. The level of Tau in putamen and caudate nucleus increased significantly.</p><p><b>CONCLUSION</b>Long-term STN HFS can increase the level of glutamate and taurine, while decrease the level of GABA in putamen and caudate nucleus of electrodes side. It improves symptoms of hemi-parkinsonian rhesus monkey significantly.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Enfermedad de Parkinson Secundaria
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Taurina
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Terapéutica
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1-Metil-4-fenil-1,2,3,6-Tetrahidropiridina
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Cromatografía Líquida de Alta Presión
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Microdiálisis
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Neurotransmisores
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Ácido Glutámico
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Cuerpo Estriado
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Núcleo Subtalámico
Límite:
Animals
Idioma:
Zh
Revista:
Chinese Journal of Surgery
Año:
2007
Tipo del documento:
Article