Combination of AD5-10 and epirubicin in treating rheumatoid arthritis / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
; (6): 367-370, 2011.
Article
en Zh
| WPRIM
| ID: wpr-341401
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the mechanism of anti-death receptor 5-10 (AD5-10) combined with epirubicin in treating rheumatoid arthritis (RA).</p><p><b>METHODS</b>We detected the cell viability of the fibroblast-like synoviocytes (FLS) from RA patients with MTT. The expression level of apoptosis signaling pathways protein, p53, and p21 were evaluated with Western blot.</p><p><b>RESULTS</b>We found that epirubicin, at different doses, could enhance the effect of AD5-10 on FLS, promoting the apoptosis of FLS. The expression levels of caspase-3, -8, -9, c-FLIP, Bcl-2, p53, and p21 in the FLS changed after epirubicin treatment.</p><p><b>CONCLUSION</b>Epirubicin may coordinate with AD5-10 in inducing FLS apoptosis through affecting the levels of p53, p21, c-FLIP, and Bcl-2.</p>
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Patología
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Farmacología
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Artritis Reumatoide
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Membrana Sinovial
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Epirrubicina
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Células Cultivadas
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Apoptosis
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Biología Celular
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Quimioterapia
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Alergia e Inmunología
Límite:
Humans
Idioma:
Zh
Revista:
Acta Academiae Medicinae Sinicae
Año:
2011
Tipo del documento:
Article