Synthesis and anti-histamine release activity of phenyl tetrazole compounds / 药学学报
Acta Pharmaceutica Sinica
; (12): 1112-1117, 2009.
Article
en Zh
| WPRIM
| ID: wpr-344048
Biblioteca responsable:
WPRO
ABSTRACT
Ongoing effort to find novel antiasthmatic drugs led to the design and synthesis of a series of compounds bearing phenyl tetrazole group based on the SAR study. The important intermediate 3-(1H-tetrazol-5-yl) benzenamine was synthesized from m-nitroaniline via cyclization and hydrogenation. Followed by amidation, eight new target compounds were obtained. The structures of these compounds were confirmed with 1H NMR, ESI-MS and elemental analysis. Their non-specific and specific anti-histamine effects in the mast cell were determined. Compound NP03 could inhibit non-specific histamine release induced by compound 48/80 in mast cell of SD rats.
Texto completo:
1
Base de datos:
WPRIM
Asunto principal:
Farmacología
/
Relación Estructura-Actividad
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Tetrazoles
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Estructura Molecular
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Química
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Ratas Sprague-Dawley
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P-Metoxi-N-metilfenetilamina
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Antiasmáticos
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Liberación de Histamina
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Mastocitos
Límite:
Animals
Idioma:
Zh
Revista:
Acta Pharmaceutica Sinica
Año:
2009
Tipo del documento:
Article