Primary vaccination of infants against hepatitis B can be completed using a combined hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliomyelitis-Haemophilus influenzae type B vaccine
Annals of the Academy of Medicine, Singapore
; : 801-806, 2007.
Artículo
en Inglés
| WPRIM (Pacífico Occidental)
| ID: wpr-348390
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>INTRODUCTION</b>Children in Singapore receive vaccination against hepatitis B virus (HBV) at 0, 1 and 5 or 6 months of age, and vaccination against pertussis, diphtheria, tetanus, and polio at 3, 4 and 5 months of age. Parents often choose to vaccinate with the combined acellular-pertussis-inactivated polio-Hib vaccine (DTPa-IPV/Hib). We investigated whether a combined hexavalent vaccine, DTPa-HBV-IPV/Hib, could replace the separate administration of DTPa-IPV/Hib and HBV for the final vaccination at 5 months of age (Trial DTPa-HBV-IPV-075).</p><p><b>MATERIALS AND METHODS</b>In an open study, 150 children were randomised to complete their vaccination schedule with DTPa-IPV/Hib + HBV or DTPa-HBV-IPV/Hib.</p><p><b>RESULTS</b>One month after the final vaccination, there was no difference between groups in seroprotection rates or antibody concentrations against HBV. Seroprotection rates against diphtheria, tetanus, Hib and polio, as well as vaccine response rates to pertussis antigens were also similar between groups. Local and general symptoms occurred at a similar rate after the third dose of either vaccine.</p><p><b>CONCLUSION</b>The immunogenicity and reactogenicity of the hexavalent vaccine DTPa-HBV-IPV/Hib (Infanrix hexa, GSK) group is comparable to that of separately administered DTPa-IPV/Hib and HBV vaccines. Combined hexavalent vaccine, DTPa-HBV-IPV/Hib, could replace the separate administration of DTPa-IPV/Hib and HBV for vaccination at 5 months of age, thereby reducing the number of injections required.</p>
Texto completo:
Disponible
Contexto en salud:
ODS3 - Salud y Bienestar
/
Enfermedades Desatendidas
/
ODS3 - Meta 3.3 Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
Problema de salud:
Meta 3.3: Poner fin a las enfermedades desatendidas y detener enfermedades transmisibles
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Zoonosis
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Hepatitis
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Meningitis
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Singapur
/
Tétanos
/
Sangre
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Vacuna Antipolio de Virus Inactivados
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Vacunas de Productos Inactivados
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Vacuna contra Difteria, Tétanos y Tos Ferina
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Haemophilus influenzae
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Esquemas de Inmunización
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Vacunación
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Vacunas contra Hepatitis B
Tipo de estudio:
Ensayo clínico controlado
Límite:
Femenino
/
Humanos
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Lactante
/
Masculino
/
Recién nacido
País/Región como asunto:
Asia
Idioma:
Inglés
Revista:
Annals of the Academy of Medicine, Singapore
Año:
2007
Tipo del documento:
Artículo