Amelioration of icariin for the epididymis impairment induced by streptozocin (STZ) in rats / 中国应用生理学杂志
Chinese Journal of Applied Physiology
; (6): 47-50, 2013.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-358682
Biblioteca responsable:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effects of icariin on the streptozocin (STZ)-induced epididymis impair in rats.</p><p><b>METHODS</b>The epididymis impair was induced by injection of streptozocin at dosage of 60 mg/kg ip in SD rats. Animals were randomly divided into six groups (n = 14) normal control, model group, three icariin treated group with different dosages (P.O, 20 mg/kg, 40 mg/kg, 80 mg/kg especially) and rosiglitazone group (P.O, 3 mg/kg), 12 weeks later, animals were sacrificed. The level of serum glucose, the activity of lactate dehydrogenase (LDH), acid phosphatase (ACP), gamma-glutamyltranspeptidase (gamma-GT), alpha-glucosidase activity as well as sialic acid (SA), fructose level in the epididymis were determined. The pathological examination was performed under microscope after the epididymis was fixed by 4% poly-formalin and stained by HE.</p><p><b>RESULTS</b>Compared with the normal control, the activity of LDH, ACP, gamma-GT and alpha-glucosidase in the epididymis revealed a decline, with lower level of SA and fructose. Histological examination showed that mature spermatocytes in the epididymis markedly decreased. These alterations were ameliorated in the groups with the treatment of icariin at 40 mg/kg and 80 mg/kg, but not at 20 mg/kg.</p><p><b>CONCLUSION</b>Icariin ameliorated the signs of epididymis in diabetic rats induced by streptozocin, this effect might carry out by promoting the elevation of special enzyme and energy metabolism in the epididymis.</p>
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Asunto principal:
Farmacología
/
Fosfatasa Ácida
/
Flavonoides
/
Glucemia
/
Ratas Sprague-Dawley
/
Ácido N-Acetilneuramínico
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Diabetes Mellitus Experimental
/
Epidídimo
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Alfa-Glucosidasas
/
Fructosa
Límite:
Animales
Idioma:
Chino
Revista:
Chinese Journal of Applied Physiology
Año:
2013
Tipo del documento:
Artículo