The molecular mechanism of astragalus polysaccharide in lowering blood-glucose and in affecting activity of PKB/Akt and translocation of GLUT4 / 中华内分泌代谢杂志

ABSTRACT

Astragalus polysaccharide (APS)was applied to treat rat model of type 2 diabetes mellitus.Blood glucose and insulin, the activity of PKB/Akt and translocation of GLUT4 in skeletal muscle of rats were examined. Results showed that AIMS decreased blood glucose, which may be related with increasing sensitivity of insulin, activity of PKB/Akt and transloeation of GLUT4 in the skeletal muscle tissue.