Expression of COX-2 and its clinical significance in non-small cell lung cancer / 中国基层医药

ABSTRACT

Objective To explore the expression of cyclooxygenase-2(COX-2) in non-small cell lung cancer (NSCLC) and its relationship with NSCLC development. Methods Expression of COX-2 protein was detected in 45 eases of NSCLC tissues and 45 cases of paracaneerous tissues by immunohistochemistry assay. Results Expression of COX-2 was detected in a significantly greater proportion of NSCLC tissues(64.4 % ) than that of paracancerous tissues(31.1% )(P＜0.05 );expression of COX-2 in different gender, age and tissue differentiation was no significant difference(P＞0.05);expression of COX-2 in adenocarcinoma was obviously higher than that in squamous carcinoma(P＜0.05);expression of COX-2 in the diameter of carcinoma tissue above 3cm was significantly higher than that below 3cm(P＜0.05) ;expression of COX-2 in carcinoma tissue existing lymphnode metastasis was obviously higher than that in non-existing lymphnode metastasis( P＜0.05 );expression of COX-2 in stage Ⅲ+Ⅳ of TNM was significantly higher than stage Ⅰ + Ⅱ of TNM(P＜0.05 ). Conclusion COX-2 was involved in occurrance and development process of lung cancer.