Influence of Aspirin on Plasma Levels of Lysophosphatidic Acid in Patients with Ischemic Cerebrovascular Diseases / 国际脑血管病杂志
International Journal of Cerebrovascular Diseases
; (12): 102-105, 2005.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-402108
Biblioteca responsable:
WPRO
ABSTRACT
To observe whether plasma levels of lysophosphatidic acid (LPA) can be decreased in patients with cerebrovascular diseases after the treatment with aspirin. Methods:
A total of 1,400 patients were recruited. Among them,803 patients were diagnosed as probable ischemic stroke,and 343 patients were diagnosed as ischemic stroke. Thirty-four health volunteers were used as control subjects. The levels of LPA were measured by chromatography with the combination of inorganic phosphorus quantitative method.Results:
The levels of LPA in the ischemic cerebrovascular group (3.11 ± 1.55 μmol/L) were significantly higher than those in the control group (1.77 ± 1.04 μmol/L) (P < 0.001). Taking aspirin (80 mg,qd) for one month significantly decreased the levels of LPA. After stopping aspirin for one month,the level of LPA re-elevated (3.90 ± 1.09 μmol/L),was higher than that during administration of aspirin (1.93 ±0.85 μmol/L(P <0.001).Conclusions:
There are close correlations between the increased levels of LPA and the platelet activation. Aspirin decreases the level of plasma LPA;this may be one of the mechanisms of aspirin in prevention against ischemic stroke.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
International Journal of Cerebrovascular Diseases
Año:
2005
Tipo del documento:
Artículo