Histone acetylation in peripheral blood mononuclear cells of type 2 diabetic patients / 中华内分泌代谢杂志
Chinese Journal of Endocrinology and Metabolism
; (12): 183-185, 2012.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-425036
Biblioteca responsable:
WPRO
ABSTRACT
Objective To study histone acetylation patterns in peripheral boiood mononuclear cells (PBMC) from type 2 diabetic patients PBMC form 12type 2 diabetic patients and 12 healthy contrcl subiects were collecyed The global histone H3/H4 acetylation was determined by assay kit The differetial expression of the histone acetyltransferases and histone deacetylases were measured by real time PCR.Results increased H3/H4 acetylation was observed in PBMC of type 2 diabetic patients compared with control subjects (H30.134±0.035vs0.181±0.032,p<0.05;H40.266±0.070VS0.324±0.062,P<0.01).the mRNA levels of p300,CREBBP,HDAC2,HDAC7,and STRTL in patients PBMC compared with healthy control subieects were 3.11±0.38,2.78±0.45,3.55±0.30,0.77±0.37 and 0.40±0.25 folds respectively conclusion histone acetylation appears abnormal in PBMC of type 2 diabetic patients.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Endocrinology and Metabolism
Año:
2012
Tipo del documento:
Artículo