Efficacy of intravenous methylprednisolone for prevention of tracheal intubation-related laryngopharyngeal complications / 中华麻醉学杂志

ABSTRACT

Objective To evaluate the efficacy of intravenous methylprednisolone for prevention of tracheal intubation-related laryngopharyngeal complications.Methods Three hundred ASA Ⅰ or Ⅱ patients,aged 20-50 yr,weighing 50-80 kg,undergoing elective surgeries,requiring tracheal intubation under general anesthesia,were included and randomized into 5 groups (n =60 each).Methylprednisolone 40 and 80 mg were injected intravenously at 30 min before induction of anesthesia in groups Ⅰ and Ⅱ,respectively,while the equal volume of normal saline was given instead in group Ⅲ.Methylprednisolone 40 and 80 mg were injected intravenously at 30 min before extubation in groups Ⅳ and Ⅴ,respectively.The sore throat,hoarseness and cough were recorded within 24 h after extubation and the severity was evaluated at 1 and 24 h after extubation.Results There was no significant difference in the incidence and severity of sore throat,hoarseness and cough between the five groups (P ＞ 0.05).Conclusion Intravenous methylprednisolone can not effectively prevent tracheal intubation-related laryngopharyngeal complications in patients.