Glycosylated hemoglobin A1c for the diagnosis of diabetes mellitus: a meta-analysis / 中华内科杂志
Chinese Journal of Internal Medicine
; (12): 21-25, 2013.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-432271
Biblioteca responsable:
WPRO
ABSTRACT
Objective To assess the diagnostic value of glycosylated hemoglobin A1c (HbA1c) ≥6.5% for diabetes in Chinese adults with oral glucose tolerance test(OGTT) as the reference standard.Methods Major databases were searched to get all diagnostic tests with HbA1c ≥ 6.5% for diabetes in Chinese adults.QUADAS items were used to evaluate the quality of the eligible studies.Meta-disc software was used to perform comprehensive quantitative assessment for all included studies and summary ROC (SROC) curve were drawn.Results A total of 11 studies were included.The outcomes of the diagnostic value with HbA1c ≥6.5% were as the followingpooled sensitivity 0.62 (95% CI0.60-0.64),pooled specificity 0.96 (95% CI0.95-0.96),diagnostic odds ratio (DOR) 40.25 (95% CI20.79-77.95) and AUCSROC 0.7702 (sx =0.0636).Conclusions The diagnostic specificity is pretty high for the diagnostic test with HbA1c ≥6.5%,while sensitivity is low.Combination of HbA1c and glucose tests is needed to reduce the missed diagnosis rate.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Tipo de estudio:
Estudio diagnóstico
/
Revisión sistemática
Idioma:
Chino
Revista:
Chinese Journal of Internal Medicine
Año:
2013
Tipo del documento:
Artículo