Effect of apoptosis and gp 130 expression by Cap preconditioning on rats of acute myocardial injured / 中国生化药物杂志
Chinese Journal of Biochemical Pharmaceutics
; (6): 43-45, 2014.
Artículo
en Chino
| WPRIM (Pacífico Occidental)
| ID: wpr-452140
Biblioteca responsable:
WPRO
ABSTRACT
Objective To study the influence of Captopril preconditioning on apoptosis and the expression of gp 130 in rats of acute myocardial injured. Method Wistar rats were randomly divided into three groupscontrol group, Iso group and Cap preconditioning group. Cardiomyocytes apoptosis was detected with TUNEL method. The expressions of Bcl-2 and Bax proteins in myocardium were tested by immunohistochemistry. The expression of gp 130 was tested with Western blot method. Results The index of cardiomyocytes apoptosis was decreased, the expressions of Bax proteins and gp 130 were decreased and the expression of Bcl-2 proteins was increased in Cap preconditioning group compared with Iso group (P<0.01 or P<0.05). Conclusion The expression of gp 130 could be decreased through Cap preconditioning, which can reduce the cardiomyocytes apoptosis.
Texto completo:
Disponible
Base de datos:
WPRIM (Pacífico Occidental)
Idioma:
Chino
Revista:
Chinese Journal of Biochemical Pharmaceutics
Año:
2014
Tipo del documento:
Artículo