Quality Evaluate of Betamethasone Tablet by Establishing a Mathematical Model / 中国药房
China Pharmacy
; (12): 417-420, 2016.
Article
en Zh
| WPRIM
| ID: wpr-501473
Biblioteca responsable:
WPRO
ABSTRACT
OBJECTIVE:To investigate the quality differences of Betamethasone tablet from different enterprises,and provide reference for the eventual establishment of the drug relative quality evaluation system. METHODS:According to the principle and steps of the ideal point method,a mathematical model was established. And the perfect point of the 3 inspection parameters (content,content uniformity and dissolution)of Betamethasone tablet was regarded as the upper limit theoretically,and the permis-sible point as the prescribed minimum in the model. After homogenizing the initial data or ones to be quantifiable were translated in-to evaluation parameters;and the evaluation parameters were calculated by ideal point method to receive comprehensive evaluation results. RESULTS:According to variance analysis,there was no significant difference in the comprehensive evaluation results of Betamethasone tablet from different enterprises(P=0.54>0.05),indicating that the overall quality of Betamehasone tablet was good. CONCLUSIONS:The mathematical model of quality evaluation with different drug has certain feasibility and operability.
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WPRIM
Idioma:
Zh
Revista:
China Pharmacy
Año:
2016
Tipo del documento:
Article