Preliminary study on plasma metabolites of total body irradiation patients / 中华放射医学与防护杂志
Chinese Journal of Radiological Medicine and Protection
; (12): 7-11, 2017.
Article
en Zh
| WPRIM
| ID: wpr-507057
Biblioteca responsable:
WPRO
ABSTRACT
Objective To investigate radiation-related human plasma metabolic features by using metabonomics method and to analyze relative metabolic pathway .Methods The plasma samples of 40 patients pre-and post-total body irradiation (TBI) from January 2012 to May 2014 were collected, and the effect of TBI on human plasma metabolites was studied by gas chromatography mass spectrometry ( GC-MS) , and the differential plasma metabolic features related to irradiation damage were screened . Results The levels of glucose, myristic acid, oxalic acid, 3-hydroxy butyric acid, urea, aspartic acid, valine, leucine, lysine and threonine in plasma were significantly (P<0.05) increased after TBI, while the levels of cholesterol, pyruvic acid, propionic acid, lactic acid, alanine, glycine, inositol, sorbitan, ethylene glycol and hypoxanthine were decreased drastically (P<0.05).Conclusions TBI could cause significant changes in the levels of human plasma metabolites including amino acid metabolism , glucose metabolism, lipid metabolism and so on.
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Base de datos:
WPRIM
Idioma:
Zh
Revista:
Chinese Journal of Radiological Medicine and Protection
Año:
2017
Tipo del documento:
Article